Hypoxia and the pulmonary circulation.

Hypoxia and the pulmonary circulation.

The first description of the effects of hypoxia on the pulmonary circulation was made by Bradford and Dean in the UK exactly 100 years ago.' However, scientific interest in this field only began with the discovery of hypoxic pulmonary vasoconstriction in the cat by von Euler and Liljestrand2 in 1946, and in man a year later in Andre Coumand's laboratory.3 Despite extensive research in this fiel...

Invited Review HIGHLIGHTED TOPIC Pulmonary Circulation and Hypoxia Hypoxia, leukocytes, and the pulmonary circulation

Stenmark, Kurt R., Neil J. Davie, John T. Reeves, and Maria G. Frid. Hypoxia, leukocytes, and the pulmonary circulation. J Appl Physiol 98: 715–721, 2005; doi:10.1152/japplphysiol.00840.2004.—Data are rapidly accumulating in support of the idea that circulating monocytes and/or mononuclear fibrocytes are recruited to the pulmonary circulation of chronically hypoxic animals and that these cells ...

Hypoxia, leukocytes, and the pulmonary circulation.

Data are rapidly accumulating in support of the idea that circulating monocytes and/or mononuclear fibrocytes are recruited to the pulmonary circulation of chronically hypoxic animals and that these cells play an important role in the pulmonary hypertensive process. Hypoxic induction of monocyte chemoattractant protein-1, stromal cell-derived factor-1, vascular endothelial growth factor-A, endo...

Hypoxia on the pulmonary circulation. How and where it acts.

Effects of acute hypoxia and exercise on the pulmonary circulation.